I Will Become a Physician Essays -- Medicine College Admissions Essays

I Will Become a Physician. Â With the ever-changing field of medication, numerous individuals wonder what medication will resemble later on. For instance, will we despite everything need to live in dread of getting a serious and savage ailment, similar to AIDS? Or then again will medication later on have the ability of taking care of such dangers to our lives? Responding to these inquiries and having the correct instruction and preparing to help forestall such dangers has been my significant aspiration. I feel that I can best satisfy this aspiration by turning into a doctor. Â I never truly thought of attending a university until the tenth grade. Much the same as my dad, I had consistently figured I would be a specialist and own my own shop since I delighted in the difficulties that emerged while diagnosing various issues in vehicles. It wasn't until I was at my primary care physician's office that I understood the likenesses between crafted by doctors and mechanics. Both expect one to analyze and tackle issues. That was the point at which I got inspired by medication. As time passed by, I began to build up an interest with the life structures, physiology, and natural chemistry of the human body. Moreover, I was flabbergasted with how doctors had the option to utilize drug to reduce torment and mend people. Thusly, these attractions to the activities of the human body and the doctor's activity drove me to seek after a profession in medication. Â During my first semester at the University of Arizona, my ... ...ollege. Fortunately, I have a family that has bolstered and empowered my achievement in school. I have additionally been lucky enough to have made it this far on my street to clinical school with the assistance of my pre-clinical consultant, pre-clinical projects (MMEP), and my coach. I realize that with their proceeded with help, I will have the option to effectively finish the educational plan expected to turn into a doctor. I know, in any case, that the way to a clinical degree will be hard and long, however I will never surrender my fantasies about turning into a doctor. I am resolved to help battle the war against those dangerous maladies like AIDS, and by turning into a doctor, I can be on that exceptional group that will have any kind of effect in a patient's life.

Puritanism Essays - Christian Philosophy, Congregationalism

Strictness The puritan religion is one that is not really comprehended in this day and age of ceaseless reasons and blame dealing. This is human instinct at it's best. Strictness most likely couldn't make it today. Truth be told, it likely wouldn't get an opportunity. The present society would not make the penances of picked hardships to make the cut. One of the most requesting religions, puritan conviction constrained its adherents to transform themselves in understanding to God's sacred word, just to figure that he might be one of the choose. The puritan religion depended on five fundamental standards; incomparability of the heavenly will, the degeneracy of man, political decision, free effortlessness, and destiny. Each having a unmistakable and overwhelming impact on all who followed and fundamentally startling the living *censored* out of individuals who didn't. To live in the puritan culture, a individual needed to play by the puritan rules, or face expulsion or even passing. The first significant conviction, and subject of extraordinary debate, was the conviction of the matchless quality of the celestial will. Just expressed, everything that occurred in the world was on the grounds that God liked it as such. In the event that God was satisfied, acceptable occasions came. In the event that he wasn't hardship and starvation followed. Another conceivable clarification to hardships, however, was that since god was acceptable, unexplainable adversely affecting wonder that appeared to be unheralded must be crafted by something outside of God's domain. This is the place not exclusively did the religion get precarious, in any case, really entered a kind of elusive incline. The Salem witch preliminaries are a prime case of this. In spite of the fact that the Bible states, Judge not, in case ye be judged, the puritans clearly didn't accept this related to them, and on the off chance that it did, they believed they were defended in attempting to protect the city on the slope. Despite the fact that in principle this perfect is innocuous, it depended on the whole assembly getting it in accordance with some basic honesty, taking it home and gulping down it. What will in general occur, then again, is that undereducated individuals when given a philosophical precept, for example, this appear to misconstrue minute things, for example, bum karma, as them being reviled, or out of god's kindness. Since it would be harder to acknowledge their own deficiencies, it would be a lot simpler to discover a substitute. As Cotton Mather exemplified in his book The Wonders of the Invisible World, insignificant issues, for example, the demise of cows, individual illness, and contamination were ascribed to black magic and magic. One such witch Martha Bearer, because of her detached after of the religion, was arraigned and condemned to death over proof that was neither seen nor demonstrated. This was acknowledged in the confidence that she was the reason for everything amiss with the distressed. (423) The following most impressive perfect was that of destiny. This conviction expressed that from the beginnings of time, God composed the content, and man was to do it with no advertisement libs. Despite the fact that this also can be viewed as a substitute instrument, this conviction despite everything radiates through in certain religions today. The contrast between most religions and the puritan religion, however, is that while different religions accepted man is fated to damnation and through the effortlessness of god may disappear to paradise, the puritans accepted that regardless of how hard a individual attempted, or how well and sacred they experienced their lives, they could sit idle to change where God needed them to wind up. Practically all Christian religions accepted that man was bound to hellfire in view of his unique sin. The degeneracy of man goes back to the Bibles story in Genesis of Adam's tumble from elegance because of his insubordination of God. Along these lines, all men were condemned to interminable condemnation. God however, sent Christ to Earth as a methods for fulfilling a new contract with man. This guaranteed probably some of humanity would be spared. This number, however, as indicated by the Puritans, was an extremely constrained sum. This was known as the procedure of political decision. This rose above to a few significant parts of the puritan culture, including the thought of free elegance. Free Grace was the conviction that there was nothing a man could do impact what God had in plan, being their last goal of paradise or hellfire. Elegance was offered uninhibitedly to his choose. The vast majority trusted themselves to be a piece of the choose, and carried on with their life for instance to other people. This at that point made a general public of grandiose individuals who trusted themselves to be a piece of the choose and most every other person to

8 Most Important Updates for You to Know on LinkedIn March 2016

8 Most Important Updates for You to Know on LinkedIn â€" March 2016 It’s hard to believe 6 months have passed since my last  What’s New on LinkedIn update in October 2015. There are a bunch of updates I want you to know about. They may have passed across your inbox, and you might have taken note, or you might not have paid attention. This summary should be all you need to make sure you’re on top of the current features on LinkedIn! Managing your settings â€" coming soon The “Privacy Settings” menu is soon going to be easier to navigate. All settings will be categorized into three groups: Account, Privacy and Communications. It will look something like this: Connection suggestions â€" coming soon LinkedIn will be suggesting more connections to you based on who has you in the contacts they’ve uploaded to LinkedIn. You will also have more control over who sees you as a suggested connection. Here’s what one of those suggestions will look like: Reminder: You can send customized messages via mobile! I mentioned this in my October update and it’s worth addressing again. Be careful when you send invitations via your mobile device. Do NOT click on “Connect” â€" you need to find the “Menu” or “More” button on an Android or the “…” on an iPhone. Here’s what that looks like on an iPhone: Next you’ll get a “Customize invite” option: Click on “Customize invite” and write your message. Your connections will appreciate you for treating them like human beings not robots. More mobile application changes LinkedIn rolled out a new and improved mobile app in December. You should now be having a better experience with its new 5 core areas, Your Feed (Home), Me, My Network, Messaging, and Search. For more info see Our New LinkedIn App is Here! Making it Easier than Ever to Stay In Touch with the People and Information you Need to be Successful. Insights on LinkedIn job postings LinkedIn has made it easier to find background information about jobs that interest you. Enjoy discovering … What connections you have at a company: Who will work with you if you get the job: Hiring trends at the company (for premium subscribers): This data puts you as a job seeker in a powerful position to understand your viability as a potential employee and to connect with the right people at the organization. Snagajob LinkedIn is providing more resources for hourly jobseekers through Snagajob. One significant implication of this partnership is that having a LinkedIn profile will become important for a wider audience. Snagajob subscribers will also get a 1-month free subscription to Lynda.com where they can take courses to acquire important skills for their profession. Inbox Messaging Honestly, LinkedIn’s Updated Messaging Features have been driving me and many people I know up a wall. Old messages are vanishing like hotcakes. I’m hoping LinkedIn will fix this soon! Introductions In October I highlighted problems with the Request an introduction feature on LinkedIn. I’m happy to report that it is now working properly! If you want to be introduced to a second degree connection, go to your mutual connection’s profile page and look on the right hand side for the “How You’re Connected” section. Click on “Get introduced” to be taken to a pre-populated messaging template that can be customized as needed. Enjoy expanding your network with this now functional feature! OK savvy LinkedIn users, have fun with all these changes. As soon as you get used to this bunch, there will be more. And if you have questions about any of these changes or others you are noticing, let me know and I’ll do my best to address them in future blogs and e-book editions!

Common Good - 969 Words

Rule 7, 2 of the Augustinian rule states: The degree to which you are concerned for the common good (rem communem) rather than for your own, is the criterion by which you can judge how much progress you have made. This passage synthesizes Augustine’s conviction regarding personal growth in Christian love. It appears in a context wherein Augustine gives the guidelines for day-to-day life in community, a life characterized by mutual service. We have already pointed out the importance of the social dimension in Augustine’s thought. Since human life is social by nature, the development of a person cannot be separated from its social context. The same applies to the new life of the believer in Christ. The new man that is born from the†¦show more content†¦The two-fold commandment of love translates into working for the common good; working for the common good is service. Theological Reflection Common good, as what we have learned, is an act of love. Love that comes from respect for others and respect for oneself. We have also learned that common good means you have to give up those things which you have in excess in order to create an equality among persons because God created us as equals. Common good creates a just and peaceful world because all of the people are in harmony with each other, are affixed to one goal, and think as one mind in Christ. In order to achieve common good we must relieve our hearts with the selfishness and biases that we have against others and we must focus on the universal outcome of our actions. So we have learned that before we act we should first think about the consequences of our actions. We must first ask ourselves of whether we are a help to the community, or whether we are placing a risk to others. So before we end we have prepared a simple thought to ponder upon: We live in a world full of inequalities and selfishness. Love has long been buried in the hearts of men that we forgot that love is the greatest gift our God has ever given us. Let us not forget that how we treat others reflects to how we treat ourselves. May we relieve ourselves from the biases that we have for others and help one another toShow MoreRelatedCommon Goods Testing1535 Words   |  7 Pagesit could lead to major lawsuits and they did not want to deal with these ethical issues. In this paper, I will apply steps A through D of the Utility Test to this case and I will also apply the Common Good Test to this case as well. After comparing and contrasting the Utility Test with the Common Good Test, I will then determine which test is the most informative in terms of my evaluation of the case. Utility Test Steps in the Sole Remaining Supplier Case â€Å"For the utility test (or â€Å"UtilitarianRead MoreCommon Core Not for the Common Good1065 Words   |  5 PagesStatistics, which issued the U.S. report on PISA.† (Heitin). From the outside the initiative, â€Å"Common Core† that President Obama and the government have been pushing since 2009 seems like it would be a great thing for education ,our children, and the future of our society, but once you look closer it is not. I believe that we definitely need serious improvement in the US educational system; but Common Core is not the answer. We as citizens, whether we have children in the school system or not shouldRead MoreIs Education A Common Good?1299 Words   |  6 Pagesmost or the best usually wins. Whether its the most wealth, the most power, the most influence, or when speaking of education, the most opportunity; starting out on top has life altering advantages. Many Americans would argue that Education is a common good, a stepping-stone through whic h students can make something better of their futures. Therefore, should society set up a system to create winners and losers in education? There are also those who believe that serving children, stakeholders, and ourRead MoreThe Main Elements Of Society For Aristotle And Plato1962 Words   |  8 Pagesthe slave, are natural parts in his holistic model of the city. Whereas, Plato considers the household as an apolitical entity which groups private interests that goes against the common and social good. Indeed, Plato will propose to dissolve family ties of the ruling class and to put in place a community of common goods, children and women. First of all, in order to understand the differences for Aristotle between a household and a city, we should first explore Aristotle’s conception of unity asRead MoreRationality Is A Common Good2044 Words   |  9 Pagesâ€Å"Rationalism in philosophy consists of arriving at substantive conclusions without appealing to any data†, stated Ken Binmore. This means that if we think that something is good, meaning that it is good for everyone, we know that we are acting in a rational manner. If it is a common good, is an objective point of view. But, if every good choice is objective, why is it that not everyone prefers the same thing? Everyone chooses according to his or her preferences and beliefs, which are different for everyoneRead MoreThe Common Goods Or Goals Of The Eu1487 Words   |  6 PagesBy definition, a supranational organization is one which, â€Å"extends beyond or transcends established borders or spheres of influence held by separate nations† (Hank s, 1991). This concept is applied to the ECJ as an emphasis on â€Å"the common goods or goals of the EU, as opposed to the separate interests of member states† (McCormick Olsen, 2013). The ECJ effectively balances the member states’ need for representation by retaining a slightly intergovernmental element to achieve the goal of an integratedRead MoreThe Argument For A Politics Of The Common Good956 Words   |  4 Pagesfor a politics of the common good in order to develop and maintain social unity, is based on their idea that the self is constituted by the community. For them, it is not individuals who examine and define their own ends, as such ends have already been developed by, and exist within, a given community. According to communitarians, individuals discover their self by deeply immersing themselves in the community s way of life, internalising the community s conceptions of good, and embracing socialRead MoreThe Issues Of Diversity, The Common Good And The. Essay1380 Words   |  6 Pagesproblems of Diversity, the common good and the Grappling with the idealism and realism, Chaantal Delsol adopts the ideas of many political theorists to paint a picture of ideal international politics by discussing war and international law from a lens of an idealist while embracing the principles of realism when evaluating morality. When discussing all topics, Delsol consistently pushes the need for diversity and how it is necessary for political life and achieving the common good – Aristotle. DelsolRead MoreAnalysis Of The Odds And Against The Common Good990 Words   |  4 Pagesphenomenon, each individual person has a 1 in 175,223,510 chance of hitting the jackpot (AmericanStatisticalAssociation.org). The author of â€Å"Against The Odds and Against the Common Good†, argues that the state lotteries are â€Å"urging people to gamble†. Gloria Jimenez, of whom is the author of â€Å"Against The Odds and Against the Common Good†, creates assumptions that support her stance on her argument. Jimenez also uses the viewpoint from people who disagree with her logic, by stating various counter statementsRead MoreThe Cost of Fighting for Social Justice and the Common Good941 Words   |  4 PagesWhat is the cost of fighting for social justice and the common good? When a person decides to set about on the journey of pursuing the good life they will face many challenges and obstacles. The good life is making decisions and executing actions that in the end will make an individual happy. But it is also satisfying a purpose in life. One cannot attain a good life throughout their lifetime if they did not serve a purpose. Moreover, increasing the happiness of others and society as a whole is another

Essay Ethical Dilemmas in Psychology - 1786 Words

Francis Bacon helped to pioneer the new science steering people away from Aristotelian teachings. He helped to bring the scientific method to a place of learning from observation and experimentation. He felt that science should be judged by the usefulness of the results (Greenwood, 2009). Bacon projected that many great things might come out of this empirical approach, but what has ensued in the centuries that followed, Bacon and others might not have predicted. Since Bacon and others pushed for a more empirical approach, numerous discoveries have been made. During this scientific revolution throughout the 16th century was categorized with big advances such as the making of new lenses by Galileo, Kepler and Huygens leading to new†¦show more content†¦The 20th century is deemed as having the most drastic differences from the beginning of the century to the end of it with advancement in medicine such as antibiotics, advancement in chemistry leading to nuclear power and sub sequent nuclear weapons, a better understanding of DNA leading to some valuable disease cures as well as controversial stem cell research, expansion of transportation leading to an ease of transplanting people to other parts of the earth, and technology which has seemingly advanced society (Wikipedia Selection for schools – 20th century, 2008/9), or regressed society as some would argue. The 21st century has continued thus far the advancements of the late 20th century. Bacon would be proud of the advancements that the scientific method created – advancements that have led to disease control, longer life, space exploration, psychological treatment of mental health conditions, and self-help resources at our finger tips. With the advancements has come a scrutiny on the way that we, as humans, have approached finding these advancements. This has brought up the issue of ethics and questions as to how we go about getting results not just the results themselves. One issu e in particular that people are questioning ethical concerns is over interrogation. Interrogation is aShow MoreRelatedEthical Dilemma in Psychology Today760 Words   |  3 PagesIn psychology field especially in the mental health profession, strongly discourage therapist from engaging in any form of romantic relationships with former or current client. It is paramount because of the two most important encountered areas for these types of issues are termination and sexual relationships. It is not wise for a therapist to begin any form of social relationship with client after termination. The therapist has to politely and gentle inform the client that it is not a good ideaRead MoreSocial Psychology And Multiculturalism1644 Words   |  7 Pages Psychology has become an integrated part of our real life. Psychology affects life under different theories and identifications. For example, social psychology and multiculturalism work together to create the social change people aspire to. However, social psychology, according to Jahoda (2016), cannot explain the link between the social behavior and the social norms of the society and culture. Hence, social psychology could be a challenge when a person tries other cultures. Furthermore, there areRead MoreSocial Psychology And Multiculturalism1714 Words   |  7 PagesIntroduction Psychology has become an integrated part of our real life. Psychology affects life under different theories and identifications. For example, social psychology and multiculturalism work together to create the social change people aspire to. However, social psychology, according to Jahoda (2016), cannot explain the link between the social behavior and the social norms of the society and culture. Hence, social psychology could be a challenge when a person tries other cultures. FurthermoreRead MoreEthics Case Study: Clinical Psychologist Essay1244 Words   |  5 PagesAs the result of a colleague’s sudden serious illness, a clinical psychologist is asked to teach a physiological psychology course, which is definitely outside his area of expertise. The course begins in one week. The department chair recognizes that the psychologist is not competent is this area, but he is as qualified as anyone else in the department and is the only person whose schedule can accommodate the c ourse. The course is required for graduation, and several seniors will not graduateRead MoreEthical Dilemma Faced By Co Workers931 Words   |  4 PagesEthical dilemma occurs in various setting which causes harm to the individual, psychologist, and to the practice. Psychologist, therapist, and others in the helping profession need to conduct themselves in a manner: (a) to uphold integrity and honest of the profession; (b) protect the welfare of the client; and (c) making sound decisions which justify ones actions base upon the profession. Forensic psychologist based their ethical decision upon the principles based upon ones actions. There areRead MoreEthics : Ethical And Ethical Dilemmas1473 Words   |  6 Pages Ethics Help the Helper in Ethical Dilemmas Fred L. Slack University of the Rockies Abstract In ethical decision-making, there is an established way to address resolving ethical dilemmas systematically and following established decision-making steps to resolve ethical dilemmas effectively. Applied established ethical-decision making steps along with an understanding of established ethical codes is essential Here we will comprehensively discuss how a professional wouldRead MoreEthical And Ethical Principles Of Psychologists And Code Of The American Psychological Association923 Words   |  4 Pagesthoughts about the conflicting area in regards to legal proceedings and ethical constraints that I might have to encounter as a psychologist. Psychologists follow a set of standardized codes derived from the Ethical Principles of Psychologists and Code of Conduct of the American Psychological Association (APA). Relying on these codes allows psychologists to make reasonable efforts to resolve an issue without violating ethical standards. If the ethics code establishes a greater st andard of conductRead More Investigative Psychology Essay1378 Words   |  6 PagesInvestigative Psychology As stated by Bartol and Bartol (2008), investigative psychology is the application of psychological research and principles to the investigation of criminal behavior (Bartol Bartol, 2008). Investigative psychology is closely associated with criminal profiling, but there are other areas in which a forensic psychologist can participate in this particular subspecialty. An investigative psychologist maybe asked to perform a psychological autopsy, forensic hypnosis, or produceRead MoreEthical Dilemmas Of The City Versus Rural Countryside Essay1105 Words   |  5 PagesEthical dilemmas Society is defined by Merriam-Webster as, â€Å"people in general thought of as living together in organized communities with shared laws, traditions, and values.† (1). The term â€Å"society† is a very complex entity with many variables and plays a role in the interaction of people every day. So what makes up a Society? Why do we gravitate towards certain groups of people? Why do we stay in certain areas of the United States, or choose to live in the city versus the rural countryside? TheRead MorePsy 496 Week 1 Assignment Case Study Evaluating Ashford University Institutional and Program Outcomes1086 Words   |  5 PagesStudy: Evaluating Ashford University Institutional and Program Outcomes. Prior to completing this assignment, read the Ashford University Institutional Outcomes located on the Syllabus page for this course. Additionally, read the Bachelor of Arts in Psychology Program Outcomes (pg. 248) located within the Online Undergraduate Programs section of the Ashford University 2013-2014 Academic Catalog. After reviewing the information provided above, you will create a two- to three-page case study focusing

Burger King Financial Overview 06-08 Free Essays

From the balance sheet point of view, we can see that total current assets initially decreased and then remained constant. This decrease was due to a reduction in cash and cash equivalents while simultaneously net receivables increased. This essentially tells us that Burger King’s short term liquidity position took a turn for the worse. We will write a custom essay sample on Burger King Financial Overview 06-08 or any similar topic only for you Order Now On the other hand, considering the fact that long term assets such as ‘property, plant and equipment’ and ‘goodwill’ increased, therefore total assets increased during 06-08. This tells us that growth took place during the above mentioned period. Total liabilities decreased sharply in 07 but then rose again slightly in 08. This decrease was mainly due to a reduction in long term debt. However, growth was still taking place because total liabilities rose again in 08. The income statement for the fiscal year 06-08 shows an extremely healthy increase in the net income, especially from 06-07 (increase from $27 million to $148 million). This also corroborates with our initial analysis of growth taking place in the company. Referring back to the balance sheet, as mentioned before, there was a sharp decrease in cash and cash equivalents while on one hand we can see that net income has been steadily increasing. What we can gauge from these figures is that burger king has essentially been expanding its business by reinvesting cash. Total assets have increased during this period as well mainly due to an increase in fixed assets. Due to the growth in the net income, stockholder’s equity has also been increasing steadily during this period. Retained earnings as well as capital surplus have also risen considerably during this period. All of these figures point towards a profitable and growing company. From the cash flow statement, figures show that cash from operating activities has been positive and rising. Cash from investing activities, on the other hand, has been negative and we can see that most of the cash has been used in capital expenditures, yet another sign of a growing and expanding company. Dividend payments have also decreased. The sale of stock has also decreased over this period and in 08 burger king repurchased its stock which is an indicator that they were trying to improve their liquidity position. From the cash flow statement, we can see that accounts receivables as well as current liabilities have increased. The augmentation of current assets therefore was mainly due to a rise in the value of the account receivables. However, both current liabilities and assets have increased during 07-08 which has resulted in the value of the current ratio remaining just below 1. Therefore, the liquidity position has remained stable although not as good as it should be. Referring back to the balance sheet, we can also that long term debt rose during 07-08. This might have essentially led to an increase in the interest expense of that year. From an overall point of view, we can see that burger king is a profitable and growing company. Every financial statement essentially hints towards a moderate expansion policy. The fact that net income has been steadily increasing tells us that burger king has been extremely profitable. If it continues to operate in the same manner, it will be able to sustain this growth, keep its investors happy and finance future expansion in an efficient manner. Sources: http://finance. yahoo. com/q? s=BKC William Haka Bettner, . Financial and Managerial Accounting. : McGraw-Hill/Irwin, 2003. How to cite Burger King Financial Overview 06-08, Papers

The Triumph of White Men’s Democracy free essay sample

Then check out the hotels of the 1820s and 30s. The poor and the rich stayed in rooms next to each other, ate at the same tables, and walked in the same halls. However, there were limits to this type of equality†¦especially if you were not white. In theory, you got in if you could pay. But this was true only for white men. Democracy came to reflect the idea of popular sovereignty Also social leveling and the decline of deference Opportunity and self-made men were the order of the day The founding fathers considered democracy to be direct rule of the people A concept they feared and rejected Jacksonians considered â€Å"the voice of the people† to be â€Å"the voice of God† Democracy and Society No one could expect social privilege because of family ties European visitors noted the lack of first class accommodations The word â€Å"servant† was disappearing; in its place was â€Å"help† Domestic workers were not considered a social subclass Members of different earning groups dressed similarly Democracy expressed itself in medicine, law and religion Unorthodox â€Å"healers† were given place alongside doctors Local bars allowed lower standards in some areas The clergy came under more control of the laity The popular press became increasingly important Written and read by common people Many small venues and a few influential papers with large readership Democratic Culture Democratic expression in literature and art Popular taste v. We will write a custom essay sample on The Triumph of White Men’s Democracy or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page elite or traditional culture Romanticism was â€Å"adapted† to sentimentalism in popular literature Formulaic gothic novels sold well Possible because of increased literacy Also cheaper printing More novels written by women

Demand For Coaching Holidays To Scotland Tourism Essay Essay Example

Demand For Coaching Holidays To Scotland Tourism Essay Essay My concern has been created on the footing of cognizing that Scotland is one of the most internationally known states for its civilization and beautiful scenery. It s based on a coaching vacation for 5 darks, 6 yearss that will be suited for people who enjoy scenery, touring, civilization and heritage. It will be run by a medium sized company located in Edinburgh that is called Saltire Tours and will be aimed at European tourers. Reasons for puting the concern in Edinburgh are that it s the capital of Scotland and has some antic history for all to see. This study will be a touristry merchandise analysis of what the concern has to offer and what factors will impact the operational side of things. PEST analysis, Competitors and Consumers are all of import and will be explained exhaustively as to what and how they will impact the concern. Introduction We will write a custom essay sample on Demand For Coaching Holidays To Scotland Tourism Essay specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Demand For Coaching Holidays To Scotland Tourism Essay specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Demand For Coaching Holidays To Scotland Tourism Essay specifically for you FOR ONLY $16.38 $13.9/page Hire Writer This research study will look into the factors that could impact demand for training vacations to Scotland from the European Market. It is based on a coaching vacation run by a medium sized company based in Edinburgh that is called Saltire Tours. On completion, the study will be an analysis of the external environment and a merchandise analysis to place and warrant the cardinal characteristics of the merchandise in which the merchandise will run. Factors being analysed will include Political, Environmental, Social and Technological ( PEST ) and will demo how they impact both positively and negatively on the Coach Tour Company wining. A rival analysis will besides be carried out to measure and discourse what sort of menace ( if any ) that may present to the tour/programme. Another portion of this study will include findings for a consumer analysis to find the Market overall for the Coach Tour Company. The merchandise itself will be given in item to explicate the key characteristics a nd why it should be introduced in the touristry industry. Pest Analysis Factors that may impact Demand for manager vacations in Scotland involve: Political Environmental Social Technological Political factors that may impact manager Tourss could be recent terrorist onslaughts in Britain, which occurred in Glasgow Airport the 30th June 2007 and London 7th June 2005. Author Chris Greenwood ( 2008 ) wrote about the adult male who was behind the onslaughts Abdulla realised his mission had failed, he dressed in a ruddy and white headscarf for the concluding self-destruction onslaught on Glasgow Airport . Another job was the Icelandic Volcanic episode in April which closed European air space. These incidents could set people off going to the UK, which would impact Scots Coach Tours as they are based in Scotland. Higher degrees of security and ordinances are now put in topographic point at airdromes, which is more clip devouring for travelers, and it s more inconvenient doing people to be impatient when going. Besides rising prices rates in the UK are forcing up monetary values for visitants such as fuel costs and 17.5 % VAT which would impact Coach Tours as they use Coachs f or taking their tourers around Scotland. The Coach Company will be a member of the Green Tourism Business Scheme as it will assist promote the touristry concern to be environmentally friendly. The Coach circuit will profit from this as it will hold a positive consequence on visitants booking up for circuit bundles as visitants are now really witting of the environment and will appeal to eco-conscious visitants particularly. Social factors could affect the fact that European visitants find touring vacations really popular in the class of different vacations ( see appendix 1 ) which is good to the company as we specialise in Coach Tours in Scotland. Besides another societal factor could be the eruption of Swine Flu that has hit Scotland and assorted other topographic points throughout the UK, this may set people off going doing the touristry industry to endure. A positive societal factor could be that Scotland has a batch of historic and cultural attractive forces that people overseas would love to see ; this will promote more people to see Scotland intending a possible addition of consumers for Saltire Tours as we specialise in civilization Tourss. Technological factors could impact Saltire Tours due to the Internet now doing it possible to book straight with circuit operators which will be a positive as it saves paying the Travel Agent committee. Saltire Tours will hold their ain web site and E booklets. Besides there are new developments in aircraft engineering, which cuts down going clip being a positive for the International visitants coming to Scotland for a Culture Tour of Scotland. There are more comfy managers for touring these yearss with Television s, lavatories, and cyberspace installations on board the managers which we will take on board and supply our visitants with luxury managers during their clip with us. Rival Analysis Benchmarking We have looked at two other Tour Companies that are in the similar market. The Analysis of each company compared to ours will assist us happen out the positives and negatives of our concern and what we can make to better the Culture Coach Tour through other rivals. Haggis Adventures Their Tourss include an escapade with like-minded travelers ; conveyance and a tour usher. Saltire Tours will include Transport, Blue Badge Guides, and Accommodation, Food, Excellent Customer service and First category attractive forces as a bundle. Haggis Adventures do nt organize everything for your circuit, you have to do your ain adjustment agreements, where to eat and you might non see some of Scotland s finest attractive forces. This is decidedly a opportunity for our concern to present a bigger and better bundle for tourers that want to loosen up and hold a great clip cognizing that everything is traveling to run swimmingly and at that place wo nt be any emphasis as everything is arranged. Besides Haggis Adventures are more for the younger coevals and since the highest proportion of tourists sing Scotland are in the 20 to 60-age scope they would bask Saltire Tours better as our circuit is suited for that age class. Saltire Tours will besides specialize in Tours whereas Haggis Adventures does nt, this will be a strength to Saltire Tours. However, a failing for Saltire Tours is that Haggis Adventures have been running for 5 old ages and have experience in this field of touristry whereas Saltire Tour is merely get downing up as a trade name new merchandise. Moray Tours Moray Tours in Scotland offer quality, flexible civilization Tourss for up to six people. Whereas Saltire Tours will offer choice civilization Tourss for up to 20 people which is a strength in the touristry Industry as Saltire Tours can offer much more to the Tourists in a manner smaller circuit companies ca nt. Their Tourss merely start in Elgin whereas Saltire Tours will be really flexible and can pick visitants up from wherever the circuit group suits which is another strength for Saltire Tours. A strength that both Moray and Saltire Tours portion is the quality of the circuit ushers on their managers and the comfy managers they both use. A menace to Saltire Tours could be that Moray Tours is good known and this could impact Saltire Tours concern. Besides on their web site, there is no reference of a monetary value for Moray Tours whereas Saltire Tours gives a bundle monetary value for the whole circuit doing it stress free throughout the vacation. Consumer Analysis The market size for our concern will be comparatively large as we will be taking our Tourss at the whole of Europe. It has been found that specifically German and Italian tourers will be interested in our Tourss as Germany is the highest ranked in footings of trips, bed darks and outgo, where its ?187million figure is dual the following ranked: Italy ( Visit Scotland ) . Factsheets on these states will be sourced at the terminal of the study ( see appendices 2 A ; 3 ) Notice our mark market ( abroad ) In June 2010 to August 2010, the seasonally adjusted figure of visits by abroad occupants to the UK increased by 6 per cent to 7.6 million, when compared with the old three months. Associated disbursement by abroad occupants on visits to the UK increased by 7 per cent to ?4.4 billion ( National statistics ) . Our manager circuit company will concentrate on these months on advertisement to pull big Numberss of tourers seeing as these are the most popular months for our mark market. Visits from Europe have increased from 16.1 million in 2000 ( a 37 per cent addition ) and are now about the same as in 2000. ( Office for national Statisticss 2009 ) Besides 22.1 million of the entire 29.9 million visits to the UK in 2009 were made by air. ( Office for national Statisticss 2009 ) Therefore our consumers will be going largely by air to Scotland which will be included in the bundle monetary value. This will be good to Saltire Tours as we will be able to utilize SGIT menu block on a footing, which will be the ideal scheduled air hose for Saltire Tours visitants to wing with, as it s a flexible continuance of 5 darks, which SGIT caters for. Merchandise Analysis Description of basic merchandise offering and merchandise characteristics Our Coach Tour Company has constructed a 5 darks, 6 yearss Tour suited for people who enjoy scenery, touring, civilization and heritage. Scotland has been one of the most internationally known states for its civilization. As our state has developed over the many 100s of old ages, it has developed a civilization that is both interesting and absorbing. St. andrews cross Tours have taken clip to develop a manager circuit suitable for the International visitants that will run into all their vacation demands. They will bask life in some top category hotels, these include: The Balmoral Hotel, Thistle Hotel, Stirling Highland Hotel, Royal George Hotel and Poppies Hotel. Visit Scotland ( 2010 ) surveies show that Hotels remain the preferable adjustment for international tourers. The topographic points they will see on this 6-day circuit of Scotland will include two of the major metropoliss: Edinburgh and Glasgow. Besides Stirling, Crieff and Callander will be included in the circuit. They will see our manner of life whilst life in a tenement edifice, to sing some of our all right art galleries. We have besides included in the Tourss some of our all right whisky distilleries to see Scotland s celebrated drink and whilst they are holding merriment during the twenty-four hours, they will besides see Scots amusement at its best! This will include Scottish pipe music, Celidh, Poetry and a concert affecting Accordions and violins. Whilst the International tourers will be entertained by Scotland s well-known attractive forces such as Edinburgh Castle, Royal Mile, Sir Walter Scott s House and Stirling Castle, they will be able to wanton in Scots culinary art throughout their stay and happen out how it feels to be Scots! The hotels they will be remaining in will be no less than 3 stars and they will be situated in the countries of involvement to accommodate the Tourss to do them run every bit swimmingly as possible. This complies with the Green Tourism Business Scheme, which is the national sustainable touristry enfranchisement strategy for the UK. All the hotels are members of this strategy. Justification of why this merchandise should be produced This merchandise should be produced as Scotland does nt hold a company like Saltire Tours. There is surely Coach Tours available but none are specifically tailored down to ticket item like our concern will bring forth. Our consumers will see everything at that place is to love approximately Scotland from sing the nutrient, scenery, civilization ; they will surely cognize what it s like to experience like a true Scot by the terminal of their vacation. Another ground is that non many companies offer a unworried vacation in Scotland where all their demands are met and international tourers will non cognize where to get down on sing Scotland. Saltire Tours will organize everything from adjustment, conveyance, attractive forces, wining and dining to flushing amusement as a bundle holiday monetary value devising certain what is included is merely the best and relevant to international tourers that wish to see Scots Culture.

The use of literary devises in A MidSummer Nights Dream essays

The use of literary devises in A MidSummer Nights Dream essays Throughout William Shakespeares play, A Midsummer Nights Dream, Shakespeares characters in a sleepy state are anointed by Oberon and Puck with love-juice. This juice causes them to fall instantaneously in and out of love with each other. Although their actions are governed by the love-juice the lovers ironically believe their actions are lead by their reason. Shakespeare uses literary devises such as, satire, irony and animal imagery, to expose love as an irrational state of being. First of all, in the play Shakespeare uses satire to illustrate that the state of love makes people act irrationally. In one scene Helena begs Demetrius to treat her like a dog telling him, Use me but as your spaniel: spurn me, strike me/Neglect me, loose me; only give me leave/(Unworthy as I am) to follow you (2.1.212-214). Helena represents the people who belittle themselves for the people they love. In another scene Demetrius, anointed with love-juice tells Helena, Oh Helen goddess, nymph, perfect divine!/To what, my love, shall I compare thine eye?(3.2.140-141). This is significant because Demetrius had previously told Helena that, for that I am sick when I do look upon thee(2.1.219). Demetrius, and how he falls instantaneously in love with the woman he had denounced, shows how people who in their anxious quest for love has them grasping into thin air to find love. In addition to satire, Shakespeare uses irony to illustrate that the state of love makes people act irrationally. In the beginning of the play when Demetrius was disgusted with Helena, she pursued him still. In one scene when she finally has the love of Demetrius she is upset. We as readers expected Helena to be happy, but instead she irrationally states, You both are rivals and love Hermia/And now both rivals to mock Helena(3.2.158-159). Helena desperately seeks love, but when love seeks her she knew not what to do,...

President Truman's decision to drop Atomic Bomb Assignment

President Truman's decision to drop Atomic Bomb - Assignment Example In the words of Walker, another option available for Truman was to try a Normandy-type amphibious landing. In this case, the estimated casualty would have been anything around a million (2008, p. 9). That is, though cruel at the first sight, Truman’s decision was not less ethical given the options available at that point of time. In the words of Wainstock (2013), the Japanese government had no respect for the lives of its own citizens and was not trying to save them. For example, though Japan faced several critical military defeats along with a crumbling industrial capacity, it exhibited a reluctance to give up the war. In contrast, it adopted highly unethical practices like ‘Kamikaze’ attacks where suicide bombers were used to target American military (Wainstock, 2013, p. 56). From this point, it is only rational to assume that had the war continued, Japan would have used its every citizen as a human shield. Thus, the decision by Truman to end the war instantaneously and unconditionally was the right option at that point of time. Admittedly, Truman was advised that the power of the atomic bomb should be demonstrated to the government of Japan before its actual use so that they could take an informed decision. However, a close analysis reveals that it was not possible for Truman to do so. For example, had the demonstration failed, it would have caused serious damage to America, and Japan would have continued with increased rigor and confidence (Wainstock, 2013). In addition, even if Japanese authorities had known the power of atomic bomb, they would not have ceased. Firstly, Japan was duly warned of a â€Å"total destruction† but there was no effort from Japan to stop war. Instead, it went on adopting unethical practices like ‘Kamikaze’. However, before giving a clean chit to Truman, it is wise to assess the other side of the argument as well. Firstly, Goldberg

Corporate Strategy Research Paper Example | Topics and Well Written Essays - 1250 words

Corporate Strategy - Research Paper Example It is possible to assume that both companies have large cash reserves spent on research and development. These reserves also enable them to take risks in spending large sums for advertising and promotion. Both companies have good reputation among customers and created cost advantage from propriety know-how. S&W and Makatume take full advantage of the quality image their products have earned over time because of automated modern factories and use of modern management methods. Aggressive advertising is used by S&W as the main marketing tool that allows the company to reach wider target audience and expend internationally. Also, cooperation and assistance of such retailers as Big Boxes, allows S&W to stock many of its products. The strength of Makatume is fast growing cordless segment and innovative production facilities in Japan. Makatume has substantial advantages over S&W, especially in its ability to achieve higher levels of quality and productivity and in the availability of low-cost labor and financing. Makatume takes full advantage of these benefits in effectively competing with American firms in U.S. markets. The main weakness of S&W is market confusion between its professional and consumer power tools. In contrast to Makatume, S&W does not have a strong position in cordless market segment. Another weakness of S&W is negative attitude of its distributors caused by abuse of their market position. S&W cannot react effectively to changing market conditions because of its size and outdated product lines. S&W has a high cost structure (old technologies and high labor cost) which prevents it from rapid growth and change. The weaknesses of Makatume include lower voltage product market and importance to invest in R&D and introduce new products, higher voltage segment. It is necessary to develop specific strategies to incorporate quality into product, promotion, pricing, and distribution areas (Johnson, Scholes 2003). Opportunities Favorable economic conditions and arrival of new technologies propose both companies opportunities to grow and increase their market share. Favorable exchange rate and stable economic situation in the region provide new opportunities for the product/market expansion grid and a framework for the marketers to consider the balance of product offerings. Threats Increased competition is the main threat for both companies. The growing imports from Chine and low price products proposed by domestic and foreign competitors become a real threat for such giants as W&S and Makatume. The threat of new entrants is the main problem: new companies can reduce industry profits and specific market share for the existing products. In the case of PEPT market, the number of companies and their location are the first indicators of the intensity of competition. This competition is further heightened by the presence of substitute products. Solutions and Recommendation In order to minimize weakness and threats, S&W has to update its product lines and introduce new brand for consumer products. It will help to avoid confusion and create a unique image of its products. Restructuring and organizational change is another step to improve market and operations performance. Only in this case, S&W will be able to deal simultaneously with various day-to-day crises. New technologies and methods of manufacturing will help S&W respond to market

Discovery of a Novel Oral Antithrombotic Drug Apixaban

Discovery of a Novel Oral Antithrombotic Drug Apixaban Shuangyu Ma Background Thrombosis, which is generally defined as the formation of blood clot inside blood vessels, is a major health issue in western world. Thrombosis associated disease, such as ischemic stroke and high blood pressure, remain to be the leading causes of morbidity and mortality each year in developed countries [1]. To make things worse, thrombosis is also known as a chronic disease with episodic recurrence [2]. According the American Heart Association, thirty percent of the patients diagnosed with venous thromboembolism develop recurrence within the next 10 years [2]. The balance between thrombosis formation and bleeding is prudently regulated by the blood coagulation cascade, one of the most delicate systems in human body (figure 1, [3]). The signal transmission and amplification along the cascade was conducted by a series of trypsin-like serine proteases with high specificity, often referred as zymogens [4]. The zymogens are cleaved by the previous coagulation factor to become activated proteases, which can thereby cleave the next zymogen along the cascade and achieve the signal amplification. Blood coagulation process can be triggered by intrinsic pathway or extrinsic pathway; both are followed by the activation of common pathway. The prothrombin is then cleaved by activated factor X to generate thrombin, eventually lead to the formation of stable fibrin clot. Fig 1. Blood coagulation cascade: (figure extracted from Haematology (2nd edition) by C. J. Pallister and M. S. Watson [4]) Until now, the most well-known oral anticoagulant is warfarin, which is the current standard therapy for clinic thrombosis treatment and prevention. Despite its widely application, warfarin has a huge draw back on its dosing issue. Many of the coagulation factors, including factors II, VII, IX and X are Vitamin K dependent; the ÃŽ ³-carboxylation by Vitamin K is essential for their biological activity. Targeting on vitamin-K conversion cycle, warfarin produces an anticoagulation effect by reducing activities of the four vitamin K-dependent coagulation factors. However, the responses to warfarin can be interfered dramatically by genetic and environment factors, such as the common mutation on cytochrome P450 encoding gene, disease states variation, drug-drug interaction or even diet change [5]. Hence, warfarin treated patients need blood test regularly (often once a week or even worse) to determine a safe dosage case by case. Despite handling with great cautious, the anticoagulant-asso ciated intracerebral hemorrhage keeps increasing [2]. Thus, many efforts have been put on developing a novel antithrombotic drug with low risk and high potency. From lead to drug: the development of apixaban The drug Apixaban, approved by FDA in 2012 for thromboembolism treatment and prevention, is developed by Pfizer and Bristol-Myers Squibb to serve as an optimized risk-benefit oral anticoagulant. The mechanism of apixaban is entirely different with warfarin it specifically targets on activated coagulation factor ten (FXa), rather than vitamin K. Several clinical trial has proved its higher efficacy compared to asparin and lower risk compared to warfarin treatment [6]. Given the central position in the blood coagulation cascade, FXa evolved as an attractive drug target for developing anticoagulants. The DuPont Merck Pharmaceutical Company first launched a high throughput screening on FXa inhibitor in 1997 [7]. Because of the substrate similarity between FXa and the GPIIb/IIa receptor, they screened the compound library which was originally designed to be GPIIb/IIa receptor antagonist. A hit was found with low micromolar FXa affinity (coumpound 1, Ki= 38.5 ÃŽ ¼M). However, most of the reported FXa inhibitor in literature at that time posse the bisamindinoaryl structure, such as 2 and 3 (figure 2a). Inspired by these compounds, they modified the hit to be bisamidines and obtained the first list of leads (including compound 4), as shown in figure 2b. Aiming at a higher potency, molecular modeling studies were conducted to further optimize the lead compound, which resulted in the removal of methylene unit between the isoxazoline ring and the amidine carbonyl together with the à ¯Ã¢â‚¬Å¾Ã†â€™ substitution to the carbonyl. After the comparison of different substitution groups, they obtained compound 5 with Ki of 94 nM (Figure 3) [7]. Fig 2 a. The structure of hit compound and several known FXa inhibitor b. The bisamidine lead compounds (figure extracted from [7]). Fig 3. Effects of the amidine group position and à ¯Ã¢â‚¬Å¾Ã†â€™ substitution (figure extracted from [7]) However, as an oral drug candidate, this dibasic lead compound might not have good oral absorption due to its hydrophilicity. Therefore, the next goal is to reduce its basicity by replacing one of the amidine groups with a neutral species. The molecular modeling of compound 5 bound to FXa indicated that the p-amidine group fits in an hydrophobic aryl-binding pocket of FXa, which is consist of three aromatic residues (Trp215, Tyr99 and Phe174, figure 4a) [8]. Therefore, it is possible to replace the p-amidine with aromatic functional groups without largely interrupt the affinity. They employed a biaryl group and obtained compound 6 with only 2-fold decrease in potency. Further investigation on different substitution at the terminal phenyl ring resulted in large enhancement on potency, such as compound 7 (Ki = 6.3 nM). (Figure 4b) Fig 4 a. Effects of substitutions on terminal phenyl ring (figures extracted from [8]). b. Chemical structure of compound 6 and 7 Nevertheless, another concern emerged to be the metabolic instability, as compound 7 bears an ester side chain, which is labile to esterase once it gets inside human body. Since the corresponding acid metabolite is three-fold less potent than the original ester [9], replacing the ester side chain appears becomes the imperative next step. Again, a list of compound 7 analogs bearing different side chains were synthesized and tested. Among all the functional groups, tetrazole substitution was found to be most potent, and compound 8 (Ki= 0.52 nM) was developed with additional modification on the biaryl ring motif (figure 5a). Variation on the position of amide moiety attachment and isoxazoline aromatization resulted in compound 9 (Ki= 0.15 nM, figure 5b) [10], while further investigation on a series of five-membered heterocyclic ring gives compound 10 with equal potency (Ki= 0.15 nM, figure 5c) and lower basicity [11] . Fig 5. Chemical structure of compound 8, 9 and 10 Despite the high potency and selectivity, compound 10 is still far from perfect due to potential mutagenicity of the biarylanilines motif [12]. Therefore, the cleavage of amide bond must be prevented by either ligating or eliminating the nitrogen (figure 6). Compound 11 was developed to have the optimized pyrazole with an even higher FXa affinity (Ki = 0.03 nM). After the scaffold was settled, more compound 11 analogs with various substitution groups and terminal aromatic rings were synthesized and compared to afford the final drug candidate as compound 12 (apixaban, Ki= 0.08, figure 7a) [1]. The optimized drug selectivity towards FXa was shown in figure 7b. The therapeutic index of the final drug compared to warfarin was demonstrated in rabbit thrombosis models and shown figure 7c) [6]. The drug candidate was sent for preclinical studies followed with several clinic trials, and eventually approved by FDA for venous thromboembolism prevention after hip/knee replacement and artrial fibrillation treatment. Another clinical trial for acute venous thromboembolism is still in progress. Fig 6. Compound 11 bearing the optimized pyrazole. Fig 7 a. Apixaban (compound 12) b. In vitro Ki values of apixaban for FXa and other human enzymes with structural or functional similarities (figure extracted from [6]). c. Therapeutic index of apixaban and warfarin in rabbit models (figure extracted from [6]). Conclusion Comparing to the initial lead compound, the eventual drug changed dramatically in chemical structure, while its FXa inhibiting potency was enhanced by 107. Tracing back to each modification step, the comprehensive consideration in drug potency, selectivity, absorption, metabolism and toxicity is truly impressive and reveals the tremendous efforts embedded in a single drug. It is worth noting that molecular modeling with FXa structure played a critical role during the rational drug modification process. The discovery of apixaban also demonstrated the importance of defining new drug target in modern drug development. The success of apixaban is largely attributed to the better drug target FXa. However, the clinical trial of apixaban on acute coronary syndrome was discontinued due to increased bleeding events [6], which suggests that other anticoagulants are still in demand for treating various type of thrombosis. Reference [1] Pinto, D. J.; Orwat, M. J.; Koch, S.; Rossi, K. A.; Alexander, R. S.; Smallwood, A.; Wong, P. C.; Rendina, A. R.; Luettgen, J. M.; Knabb, R. M.; He, K.; Xin, B.; Wexler, R. R; Lam, P. Y. Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl) phenyl)-4, 5, 6, 7-tetrahydro-1 H-pyrazolo [3, 4-c] pyridine-3-carboxamide (Apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.Journal of medicinal chemistry. 2007,50, 5339-5356. [2] Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Borden, W. B., Turner, M. B et al. Heart Disease and Stroke Statistics: 2013 Update: A Report From the American Heart Association. Circulation. 2013, 127, 143-146. [3] Pallister, C. J.; Watson, M. S. Haematology, 2nd ed. Scion Publishing: Banbury, 2010; pp 336–347. [4] Krishnaswamy, S. Exositeà ¢Ã¢â€š ¬Ã‚ driven substrate specificity and function in coagulation. Journal of thrombosis and haemostasis. 2005, 3, 54-67. [5] Hirsh, J., Fuster, V., Ansell, J., Halperin, J. L. Foundation guide to warfarin therapy. Journal of the American College of Cardiology. 2003, 41, 1633-1652. [6] Wong, P. C.; Pinto, D. J.; Zhang, D. Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor.Journal of thrombosis and thrombolysis. 2011,31, 478-492. [7] Quan, M. L.; Pruitt, J. R.; Ellis, C. D.; Liauw, A. Y.; Galemmo, R. A., Jr.; Stouten, P. F. W.; Wityak, J.; Knabb, R. M.; Thoolen, M. J.; Wong, P. C.; Wexler, R. R. Bisbenzamidine isoxazoline derivatives as factor Xa inhibitors.Bioorganic Medicinal Chemistry Letters. 1997, 7, 2813-2818. [8] Quan, M. L.; Liauw, A. Y.; Ellis, C. D.; Pruitt, J. R.; Carini, D. J.; Bostrom, L. L.; Huang, P. P.; Harrison, K.; Knabb, R. M.; Thoolen, M. J.; Wong, P. C.; Wexler, R. R. Design and Synthesis of Isoxazoline Derivatives as Factor Xa Inhibitors 1. Journal of medicinal chemistry. 1999,42, 2752-2759. [9] Quan, M. L.; Ellis, C. D.; Liauw, A. Y.; Alexander, R. S.; Knabb, R. M.; Lam, G.; Wright, M. R.; Wong, P. C.; Wexler, R. R. Design and Synthesis of Isoxazoline Derivatives as Factor Xa Inhibitors 2. Journal of medicinal chemistry. 1999,42, 2760-2773. [10] Pruitt, J. R., Pinto, D. J., Estrella, M. J., Bostrom, L. L., Knabb, R. M., Wong, P. C. Wright, M. R., Wexler, R. R. Isoxazolines and isoxazoles as factor Xa inhibitors.Bioorganic medicinal chemistry letters,2000, 10, 685-689. [11] Pinto, D. J.; Orwat, M. J.; Wang, S.; Fevig, J. M.; Quan, M. L.; Amparo, E.; Cacciola, J.; Rossi, K. A.; Alexander, R. S.; Smallwood, A. M.; Luettgen, J. M.; Liang, L.; Aungst, B. J.; Wright, M. R.; Knabb, R. M.; Wong, P. C.; Wexler, R. R.; Lam, P. Y. Discovery of 1-[3-(Aminomethyl) phenyl]-N-[3-fluoro-2-(methylsulfonyl)-[1, 1-biphenyl]-4-yl]-3-(trifluoromethyl) -1H-pyrazole-5- carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa 1.Journal of medicinal chemistry. 2001, 44, 566-578. [12] Pinto, D. J.; Orwat, M. J.; Quan, M. L.; Han, Q.; Galemmo, R. A., Jr.; Amparo, E.; Wwllsg, B.; Ellisj, C.; Hek, M. Y.; Alexanderf, R. S.; Knabbb, R. M.; Mersingerg, L.; Kettnera, C.; Baih, S.; Hed, K. Wexlera, R. R.; Lam, P. 1-[3-Aminobenzisoxazol-5†²-yl]-3-trifluoromethyl -6-[2†²-(3-(R) -hydroxy-N-pyrrolidinyl) methyl-[1, 1†²]-biphen-4-yl]-1, 4, 5, 6-tetrahydropyrazolo-[3, 4-c]-pyridin -7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.Bioorganic medicinal chemistry letters. 2006,16, 4141-4147.

Earthquake in Pakistan Essay

Earthquake activity in Pakistan is mainly concentrated in the north and western sections of the country, along the boundary of the Indian plate and the Iranian and Afghan micro-plates. The Chaman Fault runs along Pakistan’s western frontier with Afghanistan from Kalat, in the northern Makran range, past Quetta and then on to Kabul, Afghanistan. A fault also runs along the Makran coast and is believed to be of the same nature as the West Coast fault along the coast of Maharashtra, India. An active subduction zone exists off the Makran coast. The great 1945 earthquake was centred in this region. This zone forms the boundary between the Arabian and the Iranian micro-plate, where the former subducts or dives beneath the latter. Thrust zones run along the Kirthar, Sulaiman and Salt ranges. There are four faults in and around Karachi and other parts of deltaic Indus, and Makran coast. The first is the Allah Bund fault that passes through Shahbundar, Jah, Pakistan Steel Mills, and runs through eastern parts of the city and ends near Cape Monz. This fault, in fact, has caused extensive damage in the past many centuries in the deltaic areas. The destruction of Bhanbhor in the 13th century and damage to Shahbundar in 1896 were caused by this fault. The other one emanates from the Rann of Kutchh. The third one is the Pubb fault which ends into Arabian sea near Makran coast and the last one is located in the lower Dadu district near Surajani and falls in the vicinity of Karachi. Tsunamis or tidal waves have also affected the coast of Pakistan. The worst case was in 1945 when an earthquake of magnitude 7. 9 struck the Makran coast, waves as high as 12 meters were reported.

Lord Byron

In `Excerpt from Don Juan`, answer the following: Select 3 stanzas from Canto I that you can explain. Do not give plot summary, so carefully choose a stanza that lends itself to analysis or some research. Write about three to four sentences. In Subject Line, identify your stanza, e.g., 44 (Canto I, Stanza 44). Stanza 5 Brave men were living before Agamemnon And since, exceeding various and Sage, A good deal like him too, though quite the same none;  Ã‚   35 But then they shone not on the Poet’s page, And so have been forgotten: – I condemn none, But can’t find any in present age Fit for my poem (that is, for my New One) So, as I said, I’ll take my friend Don Juan. –  Ã‚  Ã‚   40 In analyzing Stanza 5, it’s interesting to read as we wonder who else Byron may have considered in this poem he sat down to write. Was he considering other brave men, poets, heroes before finalizing it with Don Juan? Who were the others â€Å"a great deal like him† (Canto 1, Stanza 5, Line 35). This stanza can be more interesting to readers who examine the history of what was viewed as the scandalous controversial nature of his writing of â€Å"Don Juan† and what concessions did Byron have to end up making before it was published. Stanza 5 sums up what he was saying about heroes in the previous stanzas. Stanza 6 Most epic poets plunge â€Å"in medias res† (Horace makes this the heroic turnpike road), And then your hero tells, whene’er you please, What went before—by the way of episode, While seated after dinner at his ease,  Ã‚   45 Beside his mistress in some soft abode, Palace, or garden, paradise, or cavern, Which serves the happy couple for a tavern. The analysis of Stanza 6 lets the reader in that Byron is intentionally not following Horace’s recommendation of when to start an epic. Byron is (intentionally?) not following the rules of what at the time was being seen by other writers as the better way of starting an epic, which was in the middle. This stanza proves to us the writer is choosing not to write using the examples of Homer or Virgil but writing this epic his own way (Canto 1, Stanza 6, Lines 41-44). Stanza 7 That is the usual method, but not mine— My way is to begin with the beginning;  Ã‚   50 The regularity of my design Forbids all wandering as the worst of sinning, And therefore I shall open with a line (Although it cost me half an hour in spinning) Narrating somewhat of Don Juan’s father,  Ã‚   55 And also of his mother, if you’d rather. Although the reader isn’t aware of it until later, Byron reveals to us that he knew in advance he would digress in the poem (Canto 1, Stanza 7, Line 54). The reader now learns that was the writer Byron’s intention from the start. The reader can wonder if Byron is even conscious of how he changes some of the â€Å"traditional† epic writing in writing this work. In `Excerpt from Childe Harold`s Pilgrimage`, answer the following: 1. Does the Byronic hero know any form of Keatsian love? Yes, in that Keatsian love is often associated with â€Å"beauty-as-truth.† In Canto 2, Stanza 9 we read as Byron writes of having loved and it was still in his thoughts although he is now alone with those thoughts. We also read of this â€Å"beauty-as-truth† love in Canto III Stanza I when he relates of the love for his daughter. 2. Beginning with stanza 17, the narrator talks about Waterloo. Why? Waterloo is current to at this time to Byron. Just a few months before this, the fate of Europe had been decided because of that Battle. So it is important that the reader is aware that it is sacred ground to him. The battle was fought on June 18th, 1815 which makes this a very relevant event during his lifetime of 1788-1824. 3. In what ways is this poem about mid-life crises? Childe in this epic refers to a â€Å"knight† and we read as this knight is gloomily wandering as a vicious world-worn man. In his thoughts throughout the â€Å"pilgramage† it relates closely to a man who is going through similar thoughts a man in mid-life crises might go through as though he has already fully lived. 4. How does the Byronic hero relate to nature? Byron relates better to nature than he does to humans. In Canto 4, Stanza 178, Byron states this: There is a pleasure in the pathless woods, There is a rapture on the lonely shore. There is society where none intrudes, By the deep Sea, and music in its roar: I love not Man the less, but Nature more, From these our interviews, in which I steal From all I may be, or have been before, To mingle with the Universe, and feel What I can ne'er express, yet cannot all conceal However, in reading this piece, I feel its obvious throughout to the reader that the writer can connect more easily with nature than humans. Because most of Byron’s work is autographical in nature, this is easy to understand if the reader about Byron’personal life. References â€Å"Characteristics of the Byronic Hero.† University of Michigan. Online. Internet. 17 May 2003. (2002, February 11). Childe Harold's Pilgrimage. Retrieved May 17, 2007, from The Project Gutenberg Web site: http://www.gutenberg.org/dirs/etext04/chp110h.htm (2007). George Gordon, Lord Byron. Retrieved May 17, 2007, from Bob's Byway Web site: http://www.poeticbyway.com/xbyron.html ; ;

Examples Demonstrate Use of Subjunctive Mood in Spanish

The subjunctive mood can be daunting for English speakers who are learning Spanish. This is mostly because even though English has its own subjunctive mood,  we dont use its distinctive forms very often. Therefore, the subjunctive can often most easily be learned by studying examples of its use. What Is the Subjunctive Mood? Lets start with the basics: The mood (sometimes called the mode) of the verb either expresses the speakers attitude toward the verb or describes how the verb is used in a sentence. The most common mood—the indicative mood—is used to refer to what is real, to state facts, to make declarations. For example, the verb in Leo el libro (I am reading the book) is in the indicative mood. In contrast, the subjunctive mood is typically used in such a way that the verbs meaning relates to how the speaker feels about it. In the sentence Espero que està © feliz (I hope that she is happy), the second verb, està © (is), may or may not be reality; what is important here is the speakers attitude toward the second  half of the sentence. Examples of the Subjunctive Mood Proper uses of the subjunctive mood can best be seen through examples. In these sample sentences, the Spanish verbs are all in the subjunctive mood (even if the English verbs are not). The explanations can help you understand why the verbs are in the subjunctive mood in the first place. Quiero que no tengas frà ­o. (I want you to not be cold.)Its irrelevant whether or not the person is cold or not. The sentence expresses a wish, not necessarily reality.Siento que tengas frà ­o. (Im sorry you are cold.)The sentence expresses the speakers emotions about a perceived reality. What is important in this sentence is the speakers feelings, not if the other person is actually cold.Te doy mi chaqueta para que no tengas frà ­o. (Im giving you my coat so you wont be cold.)The sentence expresses the speakers intent, not necessarily reality.Se permite que lleven chaquetas allà ­. (People are allowed to wear jackets there.)The phrase expresses permission for an action to take place.Dile a ella que lleve una chaqueta. (Tell her to wear her jacket.)This expresses a command or wish of the speaker.Es preferible que ustedes no viajen maà ±ana a Londres. (It is preferable that you dont travel to London tomorrow.)The subjunctive is often used in giving advice.No hay nadie que tenga frà ­o. (Nobody is cold.)This is an expression of a negation of the action in a subordinate clause.Tal vez tenga frà ­o. (Perhaps he is cold.)This is an expression of doubt.Si yo fuera rico, tocarà ­a el violà ­n. (If I were a rich man, I would play the fiddle.)This is an expression of a statement contrary to fact. Note that in this English translation, were is also in the subjunctive mood. Comparing the Subjunctive and Indicitive Moods These sentence pairs show differences between the indicative and subjunctive. Note how in most of the examples, the English verb form is the same in translating the two Spanish moods. Example 1 Indicative: Es cierto que sale tarde. (It is definite that she is leaving late.)Subjunctive: Es imposible que salga tarde. Es probable que salga tarde. (It is impossible that she is leaving late. It is likely that she will leave late.)Explanation: In the indicative sentence, the early departure is presented as fact. In the others, it is not. Example 2 Indicative: Busco el carro barato que funciona. (Im looking for the cheap car that works.)Subjunctive: Busco un carro barato que funcione. (Im looking for a cheap car that works.)Explanation: In the first example, the speaker knows that there is a car that matches the description, so the indicative is used as an expression of reality. In the second example, there is doubt that such a car exists, so the subjunctive is used. Example 3 Indicative: Creo que la visitante es Ana. (I believe the visitor is Ana.)Subjunctive: No creo que la visitante sea Ana. (I dont believe the visitor is Ana.)Explanation: The subjunctive is used in the second example because the subordinate clause is negated by the main clause. Generally, the indicative is used with creer que or pensar que, while the subjunctive is used with no creer que or no pensar que. Example 4 Indicative: Es obvio que tienes dinero. (It is obvious you have money.)Subjunctive: Es bueno que tengas dinero. (It is good you have money.)Explanation: The indicative is used in the first example because it expresses reality or apparent reality. The subjunctive is used in the other example because the sentence is a reaction to the statement in the subordinate clause. Example 5 Indicative: Habla bien porque es experto. (He speaks well because hes an expert.)Subjunctive: Habla bien como si fuera experto. (He speaks well as if he were an expert.)Explanation: The subjunctive is used in the second example because its irrelevant to the sentence whether hes an expert, although the sentence suggests that he isnt. Example 6 Indicative: Quizà ¡s lo pueden hacer. (Perhaps they can do it [and Im sure of it].)Subjunctive: Quizà ¡s lo puedan hacer. (Perhaps they can do it [but I doubt it].)Explanation: In a sentence such as this, the subjunctive is used to emphasize uncertainty or doubt, while the indicative is used to emphasize certainty. Note how the Spanish verb form is used to indicate an attitude that might need further explanation in English. Example 7 Indicative: Hay polà ­ticos que tienen coraje. (There are politicians who have courage.)Subjunctive:  ¿Hay polà ­ticos que tengan coraje? (Are there politicians with courage?)Explanation: The subjunctive is used in the second example to express doubt, and it is not clear that the subject of the sentence  exists in reality. Example 8 Indicative: Llegarà © aunque mi carro no funciona. (I will arrive even though my car isnt running.)Subjunctive: Llegarà © aunque mi carro no funcione. (I will arrive even if my car isnt running.)Explanation: The indicative is used in the first sentence because the speaker knows their car isnt working. In the second sentence, the speaker doesnt know whether or not it is running, so the subjunctive is used. Example 9 Indicative: La pirà ¡mide ha sido reconstruida por el gobierno provincial. (The pyramid has been restored by the provincial government.)Subjunctive: Estoy feliz que la pirà ¡mide se haya reconstruido. (I am happy that the pyramid has been restored.)Explanation: The indicative is used in the first sentence because it is a direct statement of fact. The main point of the second example is the speakers reaction to the event, so the subjunctive is used. Example 10 Indicative: Cuando està ¡s conmigo se llena mi corazà ³n.  (When you are with me my heart is full.)Subjunctive: Cuando està ©s conmigo iremos por un helado. (When you are with me we will go for an ice cream.)Explanation: When the indicative is used with cuando in a sentence such as the first example, it refers to a recurring action. The use of the subjunctive in the second example indicates that the event has yet to take place. Finding the Subjunctive in English The subjunctive was once used in English more than it is today—it is now employed most in formal speech, not everyday conversation. Still, cases where it is still used in English might help you remember some of the instances where it is used in Spanish. Contrary-to-fact condition: If I were the president, Id keep us out of war.Expression of a desire: I would like it if he were my father.Expressions of request or advice: I insist that he go. We recommended that he fill out the form. In all the above cases, a straightforward translation to Spanish would likely use the subjunctive mood. But remember that there are numerous instances where the subjunctive is used in Spanish where we make no distinction in English.